Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

Recently, it was reported that angiopoietin-like protein 8 (ANGPTL8) was the long-sought "betatrophin" that could control pancreatic beta cell proliferation. However, studies of Angptl8(?/?) mice revealed profound reduction of triglyceride levels, but no abnormalities in glucose homeostasis. We now report that Angptl8(?/?) mice undergo entirely normal beta cell expansion in response to insulin ...

Imatinib prevents beta cell death in vitro but does not improve islet transplantation outcome

Introduction Improving islet transplantation outcome could not only bring benefits to individual patients but also widen the patient pool to which this life-changing treatment is available. Imatinib has previously been shown to protect beta cells from apoptosis in a variety of in vitro and in vivo models. The aim of this study was to investigate whether imatinib could be used to improve islet t...

Does the Appendix Location Change During Pregnancy?

Background: Early diagnosis of appendicitis is important during pregnancy.  Unlike omentom, cecum and appendix are not likely to be displaced by the growing uterus, so the concept of position change of the appendix during pregnancy is questionable. Objective: To determine the anatomical location of appendix during pregnancy. Methods: In a prospective study from October 1995 to March 1999, 291 w...

Use of Standard Form Does Not Preclude TILA Violation

Impaired face recognition does not preclude intact whole face perception

We studied intact and impaired processes in a prosopagnosic patient (RP). In Experiment 1, RP showed an inversion superiority effect with both faces and objects, with better performance when stimuli were presented upside down than in normal upright orientation. In Experiment 2, we studied the effect of face configuration directly by comparing matching performance with normal vs. scrambled faces...